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Our Mission

The Gavathiotis laboratory's research aims to elucidate and target molecular signaling mechanisms of cell death and cell surivival that are deregulated in cancer and other diseases. Our goal is to translate structural and mechanistic insights into novel pharmacologic strategies and prototype therapeutics that can lead to cures. To achieve our goal, we take an interdisciplinary approach using link chemical synthesis, structure-based design, structural biology, biochemistry, cellular and in vivo pharmacology.

Lab and Science News

12-11-2015
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf

Onyi's work on synthetic antibodies that inhibit BAX through binding to the N-terminal activation site is publisheed in the Journal Of Biological Chemistry!

was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
28-07-2015
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf

Dr. Gavathiotis' work is feutured in Albert Einstein' Cancer Center newsletter on cancer stem cell research. 

AECC Newsletter

was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
07-05-2015
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf

Dr. Gavathiotis and Dr. Kitsis Receive the 2015 AHA Collaborative Sciences Award on developing a novel drug to limit heart damage during myocardial infarction (heart attack)  Press release 

was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
12-07-2015
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf

Dr. Gavathiotis will facilitate a Leducq Transatlantic Network of Excellence with colleagues from Einstein, Rutgers New Jersey Medical School, Howard Hughes Medical Institute/University of Texas Southwestern, Kings College (London, UK), Gustave Roussy (France), University of Padua (Italy), and Maastricht University (Netherlands) for developing novel modulators of autophagy. Press release 

was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
07-05-2015
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf

Evripidis Gavathiotis, Ph.D wins a 2015 Pershing Square Sohn Prize for Young Investigators in Cancer Research.Press release by PSSCRA Dr. Gavathiotis' 2015 prize winner's page

vimeo video youtube video

was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
20-02-2015
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Tom identified a new binding site on BAX that controls BAX inhibition from 
the BCL-2 BH4 helix in a recent collaborative paper published in Molecular Cell! 
was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
11-20-2014
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf

Dr. Gavathiotis was awarded the 2014 Young Chemical Biologist Award and gave a podium presentation during the Rising Stars of Chemical Biology Session in the 3rd Annual Conference of the International Chemical Biology Society

was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
11-20-2014
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf

Two papers in the European Journal of Medicinal Chemistry and Marine Drugs report our collaborative efforts to identify Mcl-1 selective inhibitors and dual Mcl-1/Bcl-xL inhibitors based on the marinopyrole scaffold.

was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu

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