Our Mission

The Gavathiotis laboratory focuses on chemical and structural biology to elucidate and target protein interaction mechanisms of deregulated signaling pathways in cancer and other diseases. Our ultimate goal is to translate structural and mechanistic insights into novel pharmacologic strategies and develop therapeutics that can lead to cures. To achieve our goal, we take an interdisciplinary approach using chemical synthesis, structure-based design, structural biology, biochemistry, cellular and in vivo pharmacology.

 

Lab and Science News

01-07-2014
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf

Dr. Gavathiotis was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. See more

 

was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
01-07-2014

The Innovation core is funded through a National Institute of Aging PO1 Award led by Dr. Ana Maria Cuervo. Our lab will provide expertise, reagents, analysis and interpretation using chemical and structural biology technologies with the aim to assist the development of pharmacological modulation of key components of autophagy in aging.

Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
30-06-2014
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf

Michael J. Fox Foundation funds our drug discovery project targeting Parkinson's

Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
01-06-2014

Onyi received a prestigious F31 Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship by NIH. Congrats Onyi!

 

Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
01-05-2014

Denis Reyna was accepted to the Einstein Graduate Program in Biomedical Sciences. Congrats Denis!

01-03-2014

First-year medical student Joseph Gotesman describes his research to Dr. Allen M. Spiegel, the Marilyn and Stanley M. Katz Dean of Einstein. Well done Joseph!

01-09-2013

Dr. Evripidis Gavathiotis has been selected as the 2013 Sinsheimer Scholar Award recipient by the Alexandrine and Alexander L. Sinsheimer Foundation. The foundation provides "funding to individuals who demonstrate potential for making major contributions with respect to the prevention or cure of human disease."  

 

05-06-2013

Tom receives the "best poster award" in the Annual Chemical Biology Symposium organized by the New York Academy of Sciences!

29-05-2013

Dr. Gavathiotis was named one of fifteen recipients of the prestigious 2013 Kimmel Scholar Award!

The Kimmel Scholar Awards were created to advance the careers of gifted, young scientists involved in cancer research. Those selected are chosen for demonstrating the greatest promise and innovation in their work, must be in the early stages of their research career, and have not progressed far enough to have received major grants from the National Cancer Institute or other funding sources.

14-04-2013

A new paper from Anguiano et al. in Nature Chemical Biology demonstrates a structure-based design of RARα antagonists that leads to compounds that can selectively upregulate chaperone-mediated autophagy (CMA), yielding the first chemically tractable target for regulating CMA in cells!

Read paper on-line


25-03-2013

Gabrielle's Angel Foundation For Cancer Research selects Dr. Gavathiotis to receive one of the prestigious 2012 Medical Research Awards!

The Foundation funds innovative clinical or basic science research that will lead to novel therapeutic approaches that could replace, or be used in combination with existing effective therapies and improve the quality of life of patients with leukemia or lymphoma.  Since its inception, Gabrielle's Angel Foundation has proudly distributed nearly $20 million in Medical Research Awards to more than 100 of the nation's leading junior investigators.

12-02-2013

Einstein's Wilf Family Cardiovascular Research Institute highlights work ongoing in our lab: "Escaping the Executioner Protein"

Jack and Pearl Resnick Campus | 1300 Morris Park Avenue Bronx, NY 10461 | © 2013