Our Mission

The Gavathiotis laboratory focuses on chemical and structural biology to elucidate and target protein interaction mechanisms of deregulated signaling pathways in cancer and other diseases. Our ultimate goal is to translate structural and mechanistic insights into novel pharmacologic strategies and develop therapeutics that can lead to cures. To achieve our goal, we take an interdisciplinary approach using chemical synthesis, structure-based design, structural biology, biochemistry, cellular and in vivo pharmacology.

 

Lab and Science News

20-01-2015
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Tom identified a new binding site on BAX that controls BAX inhibition from 
the BCL-2 BH4 helix in a recent collaborative paper published in Molecular Cell! 
was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
20-01-2015
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf

Dr. Gavathiotis will give two oral presentations for the Division of Biological Chemistry and Division of Medicinal Chemistry at the 249th American Chemical Society National Meeting in Denver, CO.

was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
11-20-2014
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf

Dr. Gavathiotis was awarded the 2014 Young Chemical Biologist Award and gave a podium presentation during the Rising Stars of Chemical Biology Session in the 3rd Annual Conference of the International Chemical Biology Society

was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
11-20-2014
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf

Two papers in the European Journal of Medicinal Chemistry and Marine Drugs report our collaborative efforts to identify Mcl-1 selective inhibitors and dual Mcl-1/Bcl-xL inhibitors based on the marinopyrole scaffold.

was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
01-07-2014
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Evripidis Gavathiotis, Ph.D., was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf

Dr. Gavathiotis was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells. See more

 

was awarded a $1.73 million R01 grant to investigate a novel pharmacological strategy for killing cancer cells by activating the protein BAX—a key player in apoptosis, the process by which cells self-destruct. BAX performs its deadly work by puncturing the membranes of mitochondria, the energy power plants inside cells - See more at: http://www.einstein.yu.edu/features/stories/1018/nih-awards-top-$70-million-so-far-in-2014/#sthash.cYgHl34h.dpuf
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
01-07-2014

The Innovation core is funded through a National Institute of Aging PO1 Award led by Dr. Ana Maria Cuervo. Our lab will provide expertise, reagents, analysis and interpretation using chemical and structural biology technologies with the aim to assist the development of pharmacological modulation of key components of autophagy in aging.

Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
30-06-2014
Albert Einstein College of Medicine Receives Grant From The Michael J. Fox Foundation to Fund Drug Discovery Project Targeting Parkinson's - See more at: http://www.einstein.yu.edu/news/releases/1027/albert-einstein-college-of-medicine-receives-grant-from-the-michael-j-fox-foundation-to-fund-drug-discovery-project-targeting-parkinsons/#sthash.WANIvBn0.dpuf

Michael J. Fox Foundation funds our drug discovery project targeting Parkinson's

Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
01-06-2014

Onyi received a prestigious F31 Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship by NIH. Congrats Onyi!

 

Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpuf
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship - See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-095.html#sthash.lsOwWDYG.dpu
01-05-2014

Denis Reyna was accepted to the Einstein Graduate Program in Biomedical Sciences. Congrats Denis!

01-03-2014

First-year medical student Joseph Gotesman describes his research to Dr. Allen M. Spiegel, the Marilyn and Stanley M. Katz Dean of Einstein. Well done Joseph!

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